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Structures of eukaryotic ribonucleotide reductase I define gemcitabine diphosphate binding and subunit assembly
Ribonucleotide reductase (RNR) catalyzes the conversion of nucleoside diphosphates to deoxynucleoside diphosphates. Crucial for rapidly dividing cells, RNR is a target for cancer therapy. In eukaryotes, RNR comprises a heterooligomer of α(2) and β(2) subunits. Rnr1, the α subunit, contains regulator...
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| Huvudupphovsmän: | , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
National Academy of Sciences
2006
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1389703/ https://ncbi.nlm.nih.gov/pubmed/16537480 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600440103 |
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