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Leveraging Rules of Nonsense-Mediated mRNA Decay for Genome Engineering and Personalized Medicine

Nonsense-mediated mRNA decay (NMD) is a eukaryotic mRNA quality control and regulatory process that plays direct roles in human health and disease. In this Minireview, we discuss how understanding the molecular events that trigger NMD can facilitate strategic targeting of genes via CRISPR/Cas9 techn...

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Vydáno v:Cell
Hlavní autoři: Popp, Maximilian W., Maquat, Lynne E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4924582/
https://ncbi.nlm.nih.gov/pubmed/27259145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.05.053
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