CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer

Small-cell lung cancer (SCLC) is a highly aggressive subtype of lung cancer with limited treatment options. CD47 is a cell-surface molecule that promotes immune evasion by engaging signal-regulatory protein alpha (SIRPα), which serves as an inhibitory receptor on macrophages. Here, we found that CD4...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:J Clin Invest
Autori principali: Weiskopf, Kipp, Jahchan, Nadine S., Schnorr, Peter J., Cristea, Sandra, Ring, Aaron M., Maute, Roy L., Volkmer, Anne K., Volkmer, Jens-Peter, Liu, Jie, Lim, Jing Shan, Yang, Dian, Seitz, Garrett, Nguyen, Thuyen, Wu, Di, Jude, Kevin, Guerston, Heather, Barkal, Amira, Trapani, Francesca, George, Julie, Poirier, John T., Gardner, Eric E., Miles, Linde A., de Stanchina, Elisa, Lofgren, Shane M., Vogel, Hannes, Winslow, Monte M., Dive, Caroline, Thomas, Roman K., Rudin, Charles M., van de Rijn, Matt, Majeti, Ravindra, Garcia, K. Christopher, Weissman, Irving L., Sage, Julien
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2016
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922696/
https://ncbi.nlm.nih.gov/pubmed/27294525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI81603
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi