CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer

Small-cell lung cancer (SCLC) is a highly aggressive subtype of lung cancer with limited treatment options. CD47 is a cell-surface molecule that promotes immune evasion by engaging signal-regulatory protein alpha (SIRPα), which serves as an inhibitory receptor on macrophages. Here, we found that CD4...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Weiskopf, Kipp, Jahchan, Nadine S., Schnorr, Peter J., Cristea, Sandra, Ring, Aaron M., Maute, Roy L., Volkmer, Anne K., Volkmer, Jens-Peter, Liu, Jie, Lim, Jing Shan, Yang, Dian, Seitz, Garrett, Nguyen, Thuyen, Wu, Di, Jude, Kevin, Guerston, Heather, Barkal, Amira, Trapani, Francesca, George, Julie, Poirier, John T., Gardner, Eric E., Miles, Linde A., de Stanchina, Elisa, Lofgren, Shane M., Vogel, Hannes, Winslow, Monte M., Dive, Caroline, Thomas, Roman K., Rudin, Charles M., van de Rijn, Matt, Majeti, Ravindra, Garcia, K. Christopher, Weissman, Irving L., Sage, Julien
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922696/
https://ncbi.nlm.nih.gov/pubmed/27294525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI81603
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