Engineered SIRPα variants as immunotherapeutic adjuvants to anti-cancer antibodies

During oncogenesis, tumors develop mechanisms to avoid rejection by the immune system. Recent studies have identified CD47 as an anti-phagocytic “don't eat me” signal tat cancer cells employ to inhibit macrophage-mediated destruction. Here, we modified the 14 kDa binding domain of human SIRPα,...

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Detalhes bibliográficos
Main Authors: Weiskopf, Kipp, Ring, Aaron M., Ho, Chia Chi M., Volkmer, Jens-Peter, Levin, Aron M., Volkmer, Anne Kathrin, Özkan, Engin, Fernhoff, Nathaniel B., van de Rijn, Matt, Weissman, Irving L., Garcia, K. Christopher
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3810306/
https://ncbi.nlm.nih.gov/pubmed/23722425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1238856
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