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“Velcro” Engineering of High Affinity CD47 Ectodomain as Signal Regulatory Protein α (SIRPα) Antagonists That Enhance Antibody-dependent Cellular Phagocytosis

CD47 is a cell surface protein that transmits an anti-phagocytic signal, known as the “don't-eat-me” signal, to macrophages upon engaging its receptor signal regulatory protein α (SIRPα). Molecules that antagonize the CD47-SIRPα interaction by binding to CD47, such as anti-CD47 antibodies and t...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Ho, Chia Chi M., Guo, Nan, Sockolosky, Jonathan T., Ring, Aaron M., Weiskopf, Kipp, Özkan, Engin, Mori, Yasuo, Weissman, Irving L., Garcia, K. Christopher
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432284/
https://ncbi.nlm.nih.gov/pubmed/25837251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.648220
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