Improving macrophage responses to therapeutic antibodies by molecular engineering of SIRPα variants

CD47 transduces inhibitory signals through signal-regulatory protein α (SIRPα), a plasma membrane receptor expressed by macrophages. Many cancers upregulate CD47 to evade immunosurveillance. We have recently engineered SIRPα variants that potently antagonize CD47 for use as anticancer immunotherapeu...

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Auteurs principaux: Weiskopf, Kipp, Ring, Aaron M, Schnorr, Peter J, Volkmer, Jens-Peter, Volkmer, Anne Kathrin, Weissman, Irving L, Garcia, K Christopher
Format: Artigo
Langue:Inglês
Publié: Landes Bioscience 2013
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3850276/
https://ncbi.nlm.nih.gov/pubmed/24319639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.25773
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