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Improving macrophage responses to therapeutic antibodies by molecular engineering of SIRPα variants
CD47 transduces inhibitory signals through signal-regulatory protein α (SIRPα), a plasma membrane receptor expressed by macrophages. Many cancers upregulate CD47 to evade immunosurveillance. We have recently engineered SIRPα variants that potently antagonize CD47 for use as anticancer immunotherapeu...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Landes Bioscience
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3850276/ https://ncbi.nlm.nih.gov/pubmed/24319639 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.25773 |
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