Targeting macrophage checkpoint inhibitor SIRPα for anticancer therapy

The CD47/signal regulatory protein α (Cd47/SIRPα)interaction provides a macrophage immune checkpoint pathway that plays a critical role in cancer immune evasion across multiple cancers. Here, we report the engineering of a humanized anti-SIRPα monoclonal antibody (1H9) for antibody target cancer the...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Liu, Jie, Xavy, Seethu, Mihardja, Shirley, Chen, Sharline, Sompalli, Kavitha, Feng, Dongdong, Choi, Timothy, Agoram, Balaji, Majeti, Ravindra, Weissman, Irving L., Volkmer, Jens-Peter
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7406266/
https://ncbi.nlm.nih.gov/pubmed/32427583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.134728
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