Antibody therapy targeting the CD47 protein is effective in a model of aggressive metastatic leiomyosarcoma

Antibodies against CD47, which block tumor cell CD47 interactions with macrophage signal regulatory protein-α, have been shown to decrease tumor size in hematological and epithelial tumor models by interfering with the protection from phagocytosis by macrophages that intact CD47 bestows upon tumor c...

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Hlavní autoři: Edris, Badreddin, Weiskopf, Kipp, Volkmer, Anne K., Volkmer, Jens-Peter, Willingham, Stephen B., Contreras-Trujillo, Humberto, Liu, Jie, Majeti, Ravindra, West, Robert B., Fletcher, Jonathan A., Beck, Andrew H., Weissman, Irving L., van de Rijn, Matt
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2012
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340056/
https://ncbi.nlm.nih.gov/pubmed/22451919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1121629109
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