Anti-KIT monoclonal antibody inhibits imatinib-resistant gastrointestinal stromal tumor growth

Gastrointestinal stromal tumor (GIST) is the most common sarcoma of the gastrointestinal tract and arises from the interstitial cells of Cajal. It is characterized by expression of the receptor tyrosine kinase CD117 (KIT). In 70–80% of GIST cases, oncogenic mutations in KIT are present, leading to c...

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Détails bibliographiques
Auteurs principaux: Edris, Badreddin, Willingham, Stephen B., Weiskopf, Kipp, Volkmer, Anne K., Volkmer, Jens-Peter, Mühlenberg, Thomas, Montgomery, Kelli D., Contreras-Trujillo, Humberto, Czechowicz, Agnieszka, Fletcher, Jonathan A., West, Robert B., Weissman, Irving L., van de Rijn, Matt
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2013
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3587280/
https://ncbi.nlm.nih.gov/pubmed/23382202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1222893110
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