Anti-KIT monoclonal antibody inhibits imatinib-resistant gastrointestinal stromal tumor growth

Gastrointestinal stromal tumor (GIST) is the most common sarcoma of the gastrointestinal tract and arises from the interstitial cells of Cajal. It is characterized by expression of the receptor tyrosine kinase CD117 (KIT). In 70–80% of GIST cases, oncogenic mutations in KIT are present, leading to c...

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Main Authors: Edris, Badreddin, Willingham, Stephen B., Weiskopf, Kipp, Volkmer, Anne K., Volkmer, Jens-Peter, Mühlenberg, Thomas, Montgomery, Kelli D., Contreras-Trujillo, Humberto, Czechowicz, Agnieszka, Fletcher, Jonathan A., West, Robert B., Weissman, Irving L., van de Rijn, Matt
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3587280/
https://ncbi.nlm.nih.gov/pubmed/23382202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1222893110
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