Constitutive Expression of a Dominant Negative TGF-β Type II Receptor in the Posterior Left Atrium Leads to Beneficial Remodeling of Atrial Fibrillation Substrate

RATIONALE: Fibrosis is an important structural contributor to formation of atrial fibrillation (AF) substrate in heart failure (HF). TGF-β signaling is thought to be intricately involved in creation of atrial fibrosis. OBJECTIVE: We hypothesized that gene-based expression of dominant-negative type I...

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發表在:Circ Res
Main Authors: Kunamalla, Aaron, Ng, Jason, Parini, Vamsi, Yoo, Shin, McGee, Kate A., Tomson, Todd T., Gordon, David, Thorp, Edward B., Lomasney, Jon, Zhang, Qiang, Shah, Sanjiv, Browne, Suzanne, Knight, Bradley P., Passman, Rod, Goldberger, Jeffrey J., Aistrup, Gary, Arora, Rishi
格式: Artigo
語言:Inglês
出版: 2016
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4920729/
https://ncbi.nlm.nih.gov/pubmed/27217399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.115.307878
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