Targeted nonviral gene-based inhibition of Gα(i/o)-mediated vagal signaling in the posterior left atrium decreases vagal-induced atrial fibrillation

BACKGROUND: Pharmacologic and ablative therapies for atrial fibrillation (AF) have suboptimal efficacy. Newer gene-based approaches that target specific mechanisms underlying AF are likely to be more efficacious in treating AF. Parasympathetic signaling appears to be an important contributor to AF s...

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Main Authors: Aistrup, Gary L., Cokic, Ivan, Ng, Jason, Gordon, David, Koduri, Hemanth, Browne, Suzanne, Arapi, Dorina, Segon, Yogita, Goldstein, Jacob, Angulo, Abigail, Wasserstrom, J. Andrew, Goldberger, Jeffrey J., Kadish, Alan H., Arora, Rishi
Format: Artigo
Language:Inglês
Published: 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3570566/
https://ncbi.nlm.nih.gov/pubmed/21689540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2011.06.018
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