Targeted G-protein inhibition as a novel approach to decrease vagal atrial fibrillation by selective parasympathetic attenuation

AIMS: The parasympathetic nervous system is thought to play a key role in atrial fibrillation (AF). Since parasympathetic signalling is primarily mediated by the heterotrimeric G-protein, Gα(i)βγ, we hypothesized that targeted inhibition of Gα(i) interactions in the posterior left atrium (PLA) would...

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Hlavní autoři: Aistrup, Gary L., Villuendas, Roger, Ng, Jason, Gilchrist, Annette, Lynch, Thomas W., Gordon, David, Cokic, Ivan, Mottl, Steven, Zhou, Rui, Dean, David A., Wasserstrom, J. Andrew, Goldberger, Jeffrey J., Kadish, Alan H., Arora, Rishi
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2009
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709464/
https://ncbi.nlm.nih.gov/pubmed/19457892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvp148
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