Constitutive Expression of a Dominant Negative TGF-β Type II Receptor in the Posterior Left Atrium Leads to Beneficial Remodeling of Atrial Fibrillation Substrate

RATIONALE: Fibrosis is an important structural contributor to formation of atrial fibrillation (AF) substrate in heart failure (HF). TGF-β signaling is thought to be intricately involved in creation of atrial fibrosis. OBJECTIVE: We hypothesized that gene-based expression of dominant-negative type I...

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Veröffentlicht in:Circ Res
Hauptverfasser: Kunamalla, Aaron, Ng, Jason, Parini, Vamsi, Yoo, Shin, McGee, Kate A., Tomson, Todd T., Gordon, David, Thorp, Edward B., Lomasney, Jon, Zhang, Qiang, Shah, Sanjiv, Browne, Suzanne, Knight, Bradley P., Passman, Rod, Goldberger, Jeffrey J., Aistrup, Gary, Arora, Rishi
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4920729/
https://ncbi.nlm.nih.gov/pubmed/27217399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.115.307878
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