Constitutive Expression of a Dominant Negative TGF-β Type II Receptor in the Posterior Left Atrium Leads to Beneficial Remodeling of Atrial Fibrillation Substrate

RATIONALE: Fibrosis is an important structural contributor to formation of atrial fibrillation (AF) substrate in heart failure (HF). TGF-β signaling is thought to be intricately involved in creation of atrial fibrosis. OBJECTIVE: We hypothesized that gene-based expression of dominant-negative type I...

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Publicat a:Circ Res
Autors principals: Kunamalla, Aaron, Ng, Jason, Parini, Vamsi, Yoo, Shin, McGee, Kate A., Tomson, Todd T., Gordon, David, Thorp, Edward B., Lomasney, Jon, Zhang, Qiang, Shah, Sanjiv, Browne, Suzanne, Knight, Bradley P., Passman, Rod, Goldberger, Jeffrey J., Aistrup, Gary, Arora, Rishi
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4920729/
https://ncbi.nlm.nih.gov/pubmed/27217399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.115.307878
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