Dose-Responsive Gene Expression in Suberoylanilide Hydroxamic Acid (SAHA) Treated Resting CD4+ T Cells

DESIGN: Persistent latently infected CD4+ T cells represent a major obstacle to HIV eradication. Histone deacetylase inhibitors (HDACis) are a proposed activation therapy. However, off-target effects on expression in host immune cells are poorly understood. We hypothesized that HDACi-modulated genes...

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Publicado en:AIDS
Autores principales: Reardon, Brian, Beliakova-Bethell, Nadejda, Spina, Celsa A., Singhania, Akul, Margolis, David M., Richman, Douglas R., Woelk, Christopher H.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4917679/
https://ncbi.nlm.nih.gov/pubmed/26258524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0000000000000839
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