Mixed effects of suberoylanilide hydroxamic acid (SAHA) on the host transcriptome and proteome and their implications for HIV reactivation from latency

Suberoylanilide hydroxamic acid (SAHA) has been assessed in clinical trials as part of a “shock and kill” strategy to cure HIV-infected patients. While it was effective at inducing expression of HIV RNA (“shock”), treatment with SAHA did not result in a reduction of reservoir size (“kill”). We there...

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Publicado no:Antiviral Res
Main Authors: White, Cory H., Johnston, Harvey E., Moesker, Bastiaan, Manousopoulou, Antigoni, Margolis, David M., Richman, Douglas D., Spina, Celsa A., Garbis, Spiros D., Woelk, Christopher H., Beliakova-Bethell, Nadejda
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5606336/
https://ncbi.nlm.nih.gov/pubmed/26343910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2015.09.002
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