Mixed effects of suberoylanilide hydroxamic acid (SAHA) on the host transcriptome and proteome and their implications for HIV reactivation from latency

Suberoylanilide hydroxamic acid (SAHA) has been assessed in clinical trials as part of a “shock and kill” strategy to cure HIV-infected patients. While it was effective at inducing expression of HIV RNA (“shock”), treatment with SAHA did not result in a reduction of reservoir size (“kill”). We there...

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Gepubliceerd in:Antiviral Res
Hoofdauteurs: White, Cory H., Johnston, Harvey E., Moesker, Bastiaan, Manousopoulou, Antigoni, Margolis, David M., Richman, Douglas D., Spina, Celsa A., Garbis, Spiros D., Woelk, Christopher H., Beliakova-Bethell, Nadejda
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5606336/
https://ncbi.nlm.nih.gov/pubmed/26343910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2015.09.002
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