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Suberoylanilide hydroxamic acid induces limited changes in the transcriptome of primary CD4(+) T cells
OBJECTIVE: To assess the off-target effects of the histone deacetylase inhibitor (HDACi) suberoylanilide hydroxamic acid (SAHA) in human primary CD4(+) T cells. DESIGN: A pharmacologically relevant concentration (340 nmol/l) of SAHA was shown to significantly increase histone hyperacetylation by 24...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3752851/ https://ncbi.nlm.nih.gov/pubmed/23221426 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0b013e32835b3e26 |
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