Suberoylanilide hydroxamic acid (SAHA; vorinostat) causes bone loss by inhibiting immature osteoblasts

Histone deacetylase (Hdac) inhibitors are used clinically to treat cancer and epilepsy. Although Hdac inhibition accelerates osteoblast maturation and suppresses osteoclast maturation in vitro, the effects of Hdac inhibitors on the skeleton are not understood. The purpose of this study was to determ...

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Autori principali: McGee-Lawrence, Meghan E., McCleary-Wheeler, Angela L., Secreto, Frank J., Razidlo, David F., Zhang, Minzhi, Stensgard, Bridget A., Li, Xiaodong, Stein, Gary S., Lian, Jane B., Westendorf, Jennifer J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3079070/
https://ncbi.nlm.nih.gov/pubmed/21255693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2011.01.007
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