Isotope effect analyses provide evidence for an altered transition state for RNA 2′-O-transphosphorylation catalyzed by Zn(2+)

Solvent D(2)O and (18)O kinetic isotope effects on RNA 2′-O-transphosphorylation catalyzed by Zn(2+) demonstrate an altered transition state relative to specific base catalysis. A recent model from DFT calculations involving inner sphere coordination to the non-bridging and leaving group oxygens is...

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Veröffentlicht in:Chem Commun (Camb)
Hauptverfasser: Zhang, Shuming, Gu, Hong, Chen, Haoyuan, Strong, Emily, Ollie, Edward W., Kellerman, Daniel, Liang, Danni, Miyagi, Masaru, Anderson, Vernon E., Piccirilli, Joseph A., York, Darrin M., Harris, Michael E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4916458/
https://ncbi.nlm.nih.gov/pubmed/26859380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5cc10212j
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