Isotope effect analyses provide evidence for an altered transition state for RNA 2′-O-transphosphorylation catalyzed by Zn(2+)

Solvent D(2)O and (18)O kinetic isotope effects on RNA 2′-O-transphosphorylation catalyzed by Zn(2+) demonstrate an altered transition state relative to specific base catalysis. A recent model from DFT calculations involving inner sphere coordination to the non-bridging and leaving group oxygens is...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Chem Commun (Camb)
Main Authors: Zhang, Shuming, Gu, Hong, Chen, Haoyuan, Strong, Emily, Ollie, Edward W., Kellerman, Daniel, Liang, Danni, Miyagi, Masaru, Anderson, Vernon E., Piccirilli, Joseph A., York, Darrin M., Harris, Michael E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4916458/
https://ncbi.nlm.nih.gov/pubmed/26859380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5cc10212j
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados