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Altered (transition) states: Mechanisms of solution and enzyme catalyzed RNA 2′-O-transphosphorylation

Although there have been great strides in defining the mechanisms of RNA strand cleavage by 2′-O-transphosphorylation, long-standing questions remain. How do different catalytic modes such as acid/base and metal ion catalysis influence transition state charge distribution? Does the large rate enhanc...

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Bibliografiske detaljer
Main Authors: Kellerman, Daniel L., York, Darrin M., Piccirilli, Joseph A., Harris, Michael E.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4149925/
https://ncbi.nlm.nih.gov/pubmed/25023967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2014.06.010
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