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Effect of Zn(2+) binding and enzyme active site on the transition state for RNA 2′-O-transphosphorylation interpreted through kinetic isotope effects
Divalent metal ions, due to their ability to stabilize high concentrations of negative charge, are important for RNA folding and catalysis. Detailed models derived from the structures and kinetics of enzymes and from computational simulations have been developed. However, in most cases the specific...
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| Yayımlandı: | Biochim Biophys Acta |
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| Asıl Yazarlar: | , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2015
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4743498/ https://ncbi.nlm.nih.gov/pubmed/25812974 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2015.02.022 |
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