Experimental and computational analysis of the transition state for ribonuclease A-catalyzed RNA 2′-O-transphosphorylation

Enzymes function by stabilizing reaction transition states; therefore, comparison of the transition states of enzymatic and nonenzymatic model reactions can provide insight into biological catalysis. Catalysis of RNA 2′-O-transphosphorylation by ribonuclease A is proposed to involve electrostatic st...

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Detalles Bibliográficos
Main Authors: Gu, Hong, Zhang, Shuming, Wong, Kin-Yiu, Radak, Brian K., Dissanayake, Thakshila, Kellerman, Daniel L., Dai, Qing, Miyagi, Masaru, Anderson, Vernon E., York, Darrin M., Piccirilli, Joseph A., Harris, Michael E.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740856/
https://ncbi.nlm.nih.gov/pubmed/23878223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1215086110
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