Anti-infective Activity of 2-Cyano-3-Acrylamide Inhibitors with Improved Drug-Like Properties against Two Intracellular Pathogens

Due to the rise of antibiotic resistance and the small number of effective antiviral drugs, new approaches for treating infectious diseases are urgently needed. Identifying targets for host-based therapies represents an emerging strategy for drug discovery. The ubiquitin-proteasome system is a centr...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Main Authors: Passalacqua, Karla D., Charbonneau, Marie-Eve, Donato, Nicholas J., Showalter, Hollis D., Sun, Duxin, Wen, Bo, He, Miao, Sun, Hanshi, O'Riordan, Mary X. D., Wobus, Christiane E.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2016
Assuntos:
Experimental Therapeutics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914689/
https://ncbi.nlm.nih.gov/pubmed/27139470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03021-15
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