An mGlu(5)-Positive Allosteric Modulator Rescues the Neuroplasticity Deficits in a Genetic Model of NMDA Receptor Hypofunction in Schizophrenia

There is substantial evidence that NMDA receptor (NMDAR) hypofunction contributes to the pathophysiology of schizophrenia (SCZ). A recent large-scale genome-wide association study identified serine racemase (SR), the enzyme that produces the NMDAR co-agonist D-serine, as a risk gene for SCZ. Serine...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Neuropsychopharmacology
मुख्य लेखकों: Balu, Darrick T, Li, Yan, Takagi, Shunsuke, Presti, Kendall Taylor, Ramikie, Teniel S, Rook, Jerri M, Jones, Carrie K, Lindsley, Craig W, Conn, P Jeffrey, Bolshakov, Vadim Y, Coyle, Joseph T
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Nature Publishing Group 2016
विषय:
Original Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4908650/
https://ncbi.nlm.nih.gov/pubmed/26741285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2016.2
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