An mGlu(5)-Positive Allosteric Modulator Rescues the Neuroplasticity Deficits in a Genetic Model of NMDA Receptor Hypofunction in Schizophrenia

There is substantial evidence that NMDA receptor (NMDAR) hypofunction contributes to the pathophysiology of schizophrenia (SCZ). A recent large-scale genome-wide association study identified serine racemase (SR), the enzyme that produces the NMDAR co-agonist D-serine, as a risk gene for SCZ. Serine...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Neuropsychopharmacology
Main Authors: Balu, Darrick T, Li, Yan, Takagi, Shunsuke, Presti, Kendall Taylor, Ramikie, Teniel S, Rook, Jerri M, Jones, Carrie K, Lindsley, Craig W, Conn, P Jeffrey, Bolshakov, Vadim Y, Coyle, Joseph T
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4908650/
https://ncbi.nlm.nih.gov/pubmed/26741285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2016.2
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados