Complement Component C1q Programs a Pro-Efferocytic Phenotype while Limiting TNFα Production in Primary Mouse and Human Macrophages

Deficiency in complement component C1q is associated with an inability to clear apoptotic cells (efferocytosis) and aberrant inflammation in lupus, and identification of the pathways involved in these processes should reveal important regulatory mechanisms in lupus and other autoimmune or inflammato...

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Udgivet i:Front Immunol
Main Authors: Hulsebus, Holly J., O’Conner, Sean D., Smith, Emily M., Jie, Chunfa, Bohlson, Suzanne S.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2016
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4908142/
https://ncbi.nlm.nih.gov/pubmed/27379094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00230
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