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Cinnamide Derivatives of d‐Mannose as Inhibitors of the Bacterial Virulence Factor LecB from Pseudomonas aeruginosa

Pseudomonas aeruginosa is an opportunistic Gram‐negative pathogen with high antibiotic resistance. Its lectin LecB was identified as a virulence factor and is relevant in bacterial adhesion and biofilm formation. Inhibition of LecB with carbohydrate‐based ligands results in a decrease in toxicity an...

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Publicat a:ChemistryOpen
Autors principals: Sommer, Roman, Hauck, Dirk, Varrot, Annabelle, Wagner, Stefanie, Audfray, Aymeric, Prestel, Andreas, Möller, Heiko M., Imberty, Anne, Titz, Alexander
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4906503/
https://ncbi.nlm.nih.gov/pubmed/27308201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/open.201500162
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