Anti-biofilm Agents against Pseudomonas aeruginosa: A Structure–Activity Relationship Study of C-Glycosidic LecB Inhibitors

[Image: see text] Biofilm formation is a key mechanism of antimicrobial resistance. We have recently reported two classes of orally bioavailable C-glycosidic inhibitors of the Pseudomonas aeruginosa lectin LecB with antibiofilm activity. They proved efficient in target binding, were metabolically st...

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Publicat a:J Med Chem
Autors principals: Sommer, Roman, Rox, Katharina, Wagner, Stefanie, Hauck, Dirk, Henrikus, Sarah S., Newsad, Shelby, Arnold, Tatjana, Ryckmans, Thomas, Brönstrup, Mark, Imberty, Anne, Varrot, Annabelle, Hartmann, Rolf W., Titz, Alexander
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2019
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6873108/
https://ncbi.nlm.nih.gov/pubmed/31553873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b01120
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