Disease-causing mutations of RhoGDIα induce Rac1 hyperactivation in podocytes

Nephrotic syndrome (NS) describes a group of kidney disorders in which there is injury to podocyte cells, specialized cells within the kidney's glomerular filtration barrier, allowing proteins to leak into the urine. Three mutations in ARHGDIA, which encodes Rho GDP dissociation inhibitor α (GD...

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Foilsithe in:Small GTPases
Main Authors: Auguste, David, Maier, Mirela, Baldwin, Cindy, Aoudjit, Lamine, Robins, Richard, Gupta, Indra R., Takano, Tomoko
Formáid: Artigo
Teanga:Inglês
Foilsithe: Taylor & Francis 2016
Ábhair:
Research Paper
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4905261/
https://ncbi.nlm.nih.gov/pubmed/26726844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21541248.2015.1113353
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