Disease-causing mutations of RhoGDIα induce Rac1 hyperactivation in podocytes

Nephrotic syndrome (NS) describes a group of kidney disorders in which there is injury to podocyte cells, specialized cells within the kidney's glomerular filtration barrier, allowing proteins to leak into the urine. Three mutations in ARHGDIA, which encodes Rho GDP dissociation inhibitor α (GD...

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Bibliographische Detailangaben
Veröffentlicht in:Small GTPases
Hauptverfasser: Auguste, David, Maier, Mirela, Baldwin, Cindy, Aoudjit, Lamine, Robins, Richard, Gupta, Indra R., Takano, Tomoko
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4905261/
https://ncbi.nlm.nih.gov/pubmed/26726844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21541248.2015.1113353
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