Disease-causing mutations of RhoGDIα induce Rac1 hyperactivation in podocytes

Nephrotic syndrome (NS) describes a group of kidney disorders in which there is injury to podocyte cells, specialized cells within the kidney's glomerular filtration barrier, allowing proteins to leak into the urine. Three mutations in ARHGDIA, which encodes Rho GDP dissociation inhibitor α (GD...

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Vydáno v:Small GTPases
Hlavní autoři: Auguste, David, Maier, Mirela, Baldwin, Cindy, Aoudjit, Lamine, Robins, Richard, Gupta, Indra R., Takano, Tomoko
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4905261/
https://ncbi.nlm.nih.gov/pubmed/26726844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21541248.2015.1113353
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