Disease-causing mutations of RhoGDIα induce Rac1 hyperactivation in podocytes

Nephrotic syndrome (NS) describes a group of kidney disorders in which there is injury to podocyte cells, specialized cells within the kidney's glomerular filtration barrier, allowing proteins to leak into the urine. Three mutations in ARHGDIA, which encodes Rho GDP dissociation inhibitor α (GD...

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Bibliografiska uppgifter
I publikationen:Small GTPases
Huvudupphovsmän: Auguste, David, Maier, Mirela, Baldwin, Cindy, Aoudjit, Lamine, Robins, Richard, Gupta, Indra R., Takano, Tomoko
Materialtyp: Artigo
Språk:Inglês
Publicerad: Taylor & Francis 2016
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4905261/
https://ncbi.nlm.nih.gov/pubmed/26726844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21541248.2015.1113353
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