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Disease-causing mutations of RhoGDIα induce Rac1 hyperactivation in podocytes

Nephrotic syndrome (NS) describes a group of kidney disorders in which there is injury to podocyte cells, specialized cells within the kidney's glomerular filtration barrier, allowing proteins to leak into the urine. Three mutations in ARHGDIA, which encodes Rho GDP dissociation inhibitor α (GD...

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Detalhes bibliográficos
Publicado no:Small GTPases
Main Authors: Auguste, David, Maier, Mirela, Baldwin, Cindy, Aoudjit, Lamine, Robins, Richard, Gupta, Indra R., Takano, Tomoko
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4905261/
https://ncbi.nlm.nih.gov/pubmed/26726844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21541248.2015.1113353
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