PKCα phosphorylation of RhoGDI2 at Ser 31 disrupts interactions with Rac1 and decreases GDI activity

Rho family GTPases control a diverse range of cellular processes, and their deregulation has been implicated in human cancer. Guanine nucleotide dissociation inhibitors (GDIs) bind and sequester GTPases in the cytosol, restricting their actions. RhoGDI2 is a member of the GDI family that acts as a m...

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Bibliographic Details
Main Authors: Griner, Erin M., Churchill, Mair E.A., Brautigan, David L., Theodorescu, Dan
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3578973/
https://ncbi.nlm.nih.gov/pubmed/22469974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.124
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