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PKCα phosphorylation of RhoGDI2 at Ser 31 disrupts interactions with Rac1 and decreases GDI activity
Rho family GTPases control a diverse range of cellular processes, and their deregulation has been implicated in human cancer. Guanine nucleotide dissociation inhibitors (GDIs) bind and sequester GTPases in the cytosol, restricting their actions. RhoGDI2 is a member of the GDI family that acts as a m...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3578973/ https://ncbi.nlm.nih.gov/pubmed/22469974 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.124 |
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