Diacylglycerol kinase α mediates HGF-induced Rac activation and membrane ruffling by regulating atypical PKC and RhoGDI

Diacylglycerol kinases (DGKs) convert diacylglycerol (DAG) into phosphatidic acid (PA), acting as molecular switches between DAG- and PA-mediated signaling. We previously showed that Src-dependent activation and plasma membrane recruitment of DGKα are required for growth-factor-induced cell migratio...

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Hlavní autoři: Chianale, Federica, Rainero, Elena, Cianflone, Cristina, Bettio, Valentina, Pighini, Andrea, Porporato, Paolo E., Filigheddu, Nicoletta, Serini, Guido, Sinigaglia, Fabiola, Baldanzi, Gianluca, Graziani, Andrea
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2010
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840123/
https://ncbi.nlm.nih.gov/pubmed/20160093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908326107
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