SAP-MEDIATED INHIBITION OF DIACYLGLYCEROL KINASE ALPHA REGULATES TCR-INDUCED DIACYLGLYCEROL SIGNALING

Diacylglycerol kinases (DGKs) metabolize diacylglycerol (DAG) to phosphatidic acid (PA). In T lymphocytes, DGKα acts as a negative regulator of TCR signaling by decreasing diacylglycerol levels and inducing anergy. Here, we show that upon co-stimulation of the TCR with CD28 or SLAM, DGKα, but not DG...

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Autori principali: Baldanzi, Gianluca, Pighini, Andrea, Bettio, Valentina, Rainero, Elena, Traini, Sara, Chianale, Federica, Porporato, Paolo, Filigheddu, Nicoletta, Mesturini, Riccardo, Song, Shuping, Schweighoffer, Tamas, Patrussi, Laura, Baldari, Cosima Tatiana, Zhong, Xiao-Ping, van Blitterswijk, Wim J., Sinigaglia, Fabiola, Nichols, Kim E., Rubio, Ignacio, Parolini, Ornella, Graziani, Andrea
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3221890/
https://ncbi.nlm.nih.gov/pubmed/22048771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1002476
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