A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: application to acetaminophen

Obesity and nonalcoholic fatty liver disease (NAFLD) can increase susceptibility to hepatotoxicity induced by some xenobiotics including drugs, but the involved mechanisms are poorly understood. For acetaminophen (APAP), a role of hepatic cytochrome P450 2E1 (CYP2E1) is suspected since the activity...

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Publicado no:Toxicol Appl Pharmacol
Main Authors: Michaut, Anaïs, Le Guillou, Dounia, Moreau, Caroline, Bucher, Simon, McGill, Mitchell R., Martinais, Sophie, Gicquel, Thomas, Morel, Isabelle, Robin, Marie-Anne, Jaeschke, Hartmut, Fromenty, Bernard
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4904302/
https://ncbi.nlm.nih.gov/pubmed/26739624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2015.12.020
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