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Profiling of engineering hotspots identifies an allosteric CRISPR-Cas9 switch
The CRISPR-associated protein Cas9 from Streptococcus pyogenes is an RNA-guided DNA endonuclease with widespread utility for genome modification. However, the structural constraints limiting the engineering of Cas9 have not been determined. Here we experimentally profile Cas9 using randomized insert...
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| Publicat a: | Nat Biotechnol |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4900928/ https://ncbi.nlm.nih.gov/pubmed/27136077 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3528 |
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