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Establishing the allosteric mechanism in CRISPR-Cas9
Allostery is a fundamental property of proteins, which regulates biochemical information transfer between spatially distant sites. Here, we report on the critical role of molecular dynamics (MD) simulations in discovering the mechanism of allosteric communication within CRISPR-Cas9, a leading genome...
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| Publicado no: | Wiley Interdiscip Rev Comput Mol Sci |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8315640/ https://ncbi.nlm.nih.gov/pubmed/34322166 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/wcms.1503 |
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