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Allosteric Regulation of CRISPR-Cas9 for DNA Targeting and Cleavage
The CRISPR-Cas9 system from Streptococcus pyogenes has been exploited as a programmable RNA-guided DNA targeting and editing platform. This evolutionary tool enables diverse genetic manipulations with unprecedented precision and ease. Cas9 is an allosteric enzyme, which is allosterically regulated i...
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| Publicado en: | Curr Opin Struct Biol |
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| Autores principales: | , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7308215/ https://ncbi.nlm.nih.gov/pubmed/32070859 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.sbi.2020.01.013 |
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