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Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery

The CRISPR/Cas9 system is a robust genome editing technology that works in human cells, animals and plants based on the RNA-programmed DNA cleaving activity of the Cas9 enzyme. Building on previous work (Jinek et al., 2013), we show here that new genetic information can be introduced site-specifical...

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Veröffentlicht in:eLife
Hauptverfasser: Lin, Steven, Staahl, Brett T, Alla, Ravi K, Doudna, Jennifer A
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2014
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4383097/
https://ncbi.nlm.nih.gov/pubmed/25497837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.04766
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