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Sequence Context Influences the Structure and Aggregation Behavior of a PolyQ Tract

Expansions of polyglutamine (polyQ) tracts in nine different proteins cause a family of neurodegenerative disorders called polyQ diseases. Because polyQ tracts are potential therapeutic targets for these pathologies there is great interest in characterizing the conformations that they adopt and in u...

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Dettagli Bibliografici
Pubblicato in:Biophys J
Autori principali: Eftekharzadeh, Bahareh, Piai, Alessandro, Chiesa, Giulio, Mungianu, Daniele, García, Jesús, Pierattelli, Roberta, Felli, Isabella C., Salvatella, Xavier
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Biophysical Society 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4900447/
https://ncbi.nlm.nih.gov/pubmed/27276254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.04.022
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