Sequence Context Influences the Structure and Aggregation Behavior of a PolyQ Tract

Expansions of polyglutamine (polyQ) tracts in nine different proteins cause a family of neurodegenerative disorders called polyQ diseases. Because polyQ tracts are potential therapeutic targets for these pathologies there is great interest in characterizing the conformations that they adopt and in u...

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Bibliographic Details
Published in:Biophys J
Main Authors: Eftekharzadeh, Bahareh, Piai, Alessandro, Chiesa, Giulio, Mungianu, Daniele, García, Jesús, Pierattelli, Roberta, Felli, Isabella C., Salvatella, Xavier
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2016
Subjects:
Proteins
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4900447/
https://ncbi.nlm.nih.gov/pubmed/27276254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.04.022
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