Sequence Context Influences the Structure and Aggregation Behavior of a PolyQ Tract

Expansions of polyglutamine (polyQ) tracts in nine different proteins cause a family of neurodegenerative disorders called polyQ diseases. Because polyQ tracts are potential therapeutic targets for these pathologies there is great interest in characterizing the conformations that they adopt and in u...

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Detalles Bibliográficos
Publicado en:Biophys J
Autores principales: Eftekharzadeh, Bahareh, Piai, Alessandro, Chiesa, Giulio, Mungianu, Daniele, García, Jesús, Pierattelli, Roberta, Felli, Isabella C., Salvatella, Xavier
Formato: Artigo
Lenguaje:Inglês
Publicado: The Biophysical Society 2016
Materias:
Proteins
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4900447/
https://ncbi.nlm.nih.gov/pubmed/27276254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.04.022
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