Sequence Context Influences the Structure and Aggregation Behavior of a PolyQ Tract

Expansions of polyglutamine (polyQ) tracts in nine different proteins cause a family of neurodegenerative disorders called polyQ diseases. Because polyQ tracts are potential therapeutic targets for these pathologies there is great interest in characterizing the conformations that they adopt and in u...

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Vydáno v:Biophys J
Hlavní autoři: Eftekharzadeh, Bahareh, Piai, Alessandro, Chiesa, Giulio, Mungianu, Daniele, García, Jesús, Pierattelli, Roberta, Felli, Isabella C., Salvatella, Xavier
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2016
Témata:
Proteins
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4900447/
https://ncbi.nlm.nih.gov/pubmed/27276254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.04.022
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