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Sequence Context Influences the Structure and Aggregation Behavior of a PolyQ Tract
Expansions of polyglutamine (polyQ) tracts in nine different proteins cause a family of neurodegenerative disorders called polyQ diseases. Because polyQ tracts are potential therapeutic targets for these pathologies there is great interest in characterizing the conformations that they adopt and in u...
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| Published in: | Biophys J |
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| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
The Biophysical Society
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4900447/ https://ncbi.nlm.nih.gov/pubmed/27276254 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.04.022 |
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