Effects of Q/N-rich, polyQ, and non-polyQ amyloids on the de novo formation of the [PSI(+)] prion in yeast and aggregation of Sup35 in vitro

Prions are infectious protein conformations that are generally ordered protein aggregates. In the absence of prions, newly synthesized molecules of these same proteins usually maintain a conventional soluble conformation. However, prions occasionally arise even without a homologous prion template. T...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Derkatch, Irina L., Uptain, Susan M., Outeiro, Tiago F., Krishnan, Rajaraman, Lindquist, Susan L., Liebman, Susan W.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2004
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC516497/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15326312/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0404968101
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