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Effects of Q/N-rich, polyQ, and non-polyQ amyloids on the de novo formation of the [PSI(+)] prion in yeast and aggregation of Sup35 in vitro

Prions are infectious protein conformations that are generally ordered protein aggregates. In the absence of prions, newly synthesized molecules of these same proteins usually maintain a conventional soluble conformation. However, prions occasionally arise even without a homologous prion template. T...

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Detalhes bibliográficos
Main Authors: Derkatch, Irina L., Uptain, Susan M., Outeiro, Tiago F., Krishnan, Rajaraman, Lindquist, Susan L., Liebman, Susan W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC516497/
https://ncbi.nlm.nih.gov/pubmed/15326312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0404968101
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