Overexpression of Q-rich prion-like proteins suppresses polyQ cytotoxicity and alters the polyQ interactome

Expansion of a poly-glutamine (polyQ) repeat in a group of functionally unrelated proteins is the cause of several inherited neurodegenerative disorders, including Huntington’s disease. The polyQ length-dependent aggregation and toxicity of these disease proteins can be reproduced in Saccharomyces c...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Ripaud, Leslie, Chumakova, Victoria, Antonin, Matthias, Hastie, Alex R., Pinkert, Stefan, Körner, Roman, Ruff, Kiersten M., Pappu, Rohit V., Hornburg, Daniel, Mann, Matthias, Hartl, F. Ulrich, Hipp, Mark S.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2014
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4280636/
https://ncbi.nlm.nih.gov/pubmed/25489109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1421313111
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