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Essential role of coiled-coils for aggregation and activity of Q/N-rich prions and polyQ proteins
The functional switch of glutamine/asparagine (Q/N)-rich prions and the neurotoxicity of polyQ-expanded proteins involve complex aggregation-prone structural transitions, commonly presumed to be forming β-sheets. By analyzing sequences of interaction partners of these proteins, we discovered a recur...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3472970/ https://ncbi.nlm.nih.gov/pubmed/21183075 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.11.042 |
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