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The Interplay between PolyQ and Protein Context Delays Aggregation by Forming a Reservoir of Protofibrils
Polyglutamine (polyQ) diseases are inherited neurodegenerative disorders caused by the expansion of CAG codon repeats, which code for polyQ in the corresponding gene products. These diseases are associated with the presence of amyloid-like protein aggregates, induced by polyQ expansion. It has been...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science
2006
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1762411/ https://ncbi.nlm.nih.gov/pubmed/17205115 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000111 |
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