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The Interplay between PolyQ and Protein Context Delays Aggregation by Forming a Reservoir of Protofibrils

Polyglutamine (polyQ) diseases are inherited neurodegenerative disorders caused by the expansion of CAG codon repeats, which code for polyQ in the corresponding gene products. These diseases are associated with the presence of amyloid-like protein aggregates, induced by polyQ expansion. It has been...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Bulone, Donatella, Masino, Laura, Thomas, David J., San Biagio, Pier Luigi, Pastore, Annalisa
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2006
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1762411/
https://ncbi.nlm.nih.gov/pubmed/17205115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000111
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