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The Interplay between PolyQ and Protein Context Delays Aggregation by Forming a Reservoir of Protofibrils

Polyglutamine (polyQ) diseases are inherited neurodegenerative disorders caused by the expansion of CAG codon repeats, which code for polyQ in the corresponding gene products. These diseases are associated with the presence of amyloid-like protein aggregates, induced by polyQ expansion. It has been...

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Detalles Bibliográficos
Main Authors: Bulone, Donatella, Masino, Laura, Thomas, David J., San Biagio, Pier Luigi, Pastore, Annalisa
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2006
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1762411/
https://ncbi.nlm.nih.gov/pubmed/17205115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000111
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