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Stress and aging induce distinct polyQ protein aggregation states

Many age-related diseases are known to elicit protein misfolding and aggregation. Whereas environmental stressors, such as temperature, oxidative stress, and osmotic stress, can also damage proteins, it is not known whether aging and the environment impact protein folding in the same or different wa...

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Detalhes bibliográficos
Main Authors: Moronetti Mazzeo, Lorenza E., Dersh, Devin, Boccitto, Marco, Kalb, Robert G., Lamitina, Todd
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3387092/
https://ncbi.nlm.nih.gov/pubmed/22645345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1108766109
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