Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and CNS inflammation via the aryl hydrocarbon receptor

Astrocytes play important roles in the central nervous system (CNS) during health and disease. Through genome-wide analyses we detected a transcriptional response to type I interferons (IFN-I) in astrocytes during experimental CNS autoimmunity and also in CNS lesions from multiple sclerosis (MS) pat...

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Détails bibliographiques
Publié dans:Nat Med
Auteurs principaux: Rothhammer, Veit, Mascanfroni, Ivan D., Bunse, Lukas, Takenaka, Maisa C., Kenison, Jessica E., Mayo, Lior, Chao, Chun-Cheih, Patel, Bonny, Yan, Raymond, Blain, Manon, Alvarez, Jorge I., Kébir, Hania, Anandasabapathy, Niroshana, Izquierdo, Guillermo, Jung, Steffen, Obholzer, Nikolaus, Pochet, Nathalie, Clish, Clary B., Prinz, Marco, Prat, Alexandre, Antel, Jack, Quintana, Francisco J.
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4899206/
https://ncbi.nlm.nih.gov/pubmed/27158906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4106
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