Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and CNS inflammation via the aryl hydrocarbon receptor

Astrocytes play important roles in the central nervous system (CNS) during health and disease. Through genome-wide analyses we detected a transcriptional response to type I interferons (IFN-I) in astrocytes during experimental CNS autoimmunity and also in CNS lesions from multiple sclerosis (MS) pat...

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Publicado no:Nat Med
Main Authors: Rothhammer, Veit, Mascanfroni, Ivan D., Bunse, Lukas, Takenaka, Maisa C., Kenison, Jessica E., Mayo, Lior, Chao, Chun-Cheih, Patel, Bonny, Yan, Raymond, Blain, Manon, Alvarez, Jorge I., Kébir, Hania, Anandasabapathy, Niroshana, Izquierdo, Guillermo, Jung, Steffen, Obholzer, Nikolaus, Pochet, Nathalie, Clish, Clary B., Prinz, Marco, Prat, Alexandre, Antel, Jack, Quintana, Francisco J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4899206/
https://ncbi.nlm.nih.gov/pubmed/27158906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4106
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