Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and CNS inflammation via the aryl hydrocarbon receptor

Astrocytes play important roles in the central nervous system (CNS) during health and disease. Through genome-wide analyses we detected a transcriptional response to type I interferons (IFN-I) in astrocytes during experimental CNS autoimmunity and also in CNS lesions from multiple sclerosis (MS) pat...

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Publicat a:Nat Med
Autors principals: Rothhammer, Veit, Mascanfroni, Ivan D., Bunse, Lukas, Takenaka, Maisa C., Kenison, Jessica E., Mayo, Lior, Chao, Chun-Cheih, Patel, Bonny, Yan, Raymond, Blain, Manon, Alvarez, Jorge I., Kébir, Hania, Anandasabapathy, Niroshana, Izquierdo, Guillermo, Jung, Steffen, Obholzer, Nikolaus, Pochet, Nathalie, Clish, Clary B., Prinz, Marco, Prat, Alexandre, Antel, Jack, Quintana, Francisco J.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4899206/
https://ncbi.nlm.nih.gov/pubmed/27158906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4106
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